APOE Receptor (LDL Receptor) Antibody
1704.52 €
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Catalog number: 639 - abx022339-005mg
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 0.05 mg
91-784
LDL Receptor Recombinant Protein
Low-Density Lipoprotein Receptor (LDLR) is a transmembrane glycoprotein that plays a critical role in cholesterol homeostasis. LDLR mediates blood cholesterol level by interacting with lipoprotein particles like LDL and VLDL. The extracellular domain of LDLR contains LDL receptor type A (ligand-binding) modules (LA repeats), epidermal growth factor-like modules, and LY repeats containing the YWTD consensus motif that are important in binding and releasing of ApoB-100 and ApoE in lipoprotein particles. The C terminal domain of LDLR inside the cell is required for the receptor internalization. Loss of function mutations in the LDLR gene causes Familial Hypercholesterolemia (FH).
1106.95 €