Ruxolitinib . phosphate salt
663.60 €
663.60 €
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Catalog number: 862 - GW4048-100
Product Category: Business & Industrial > Science & Laboratory
Supplier:
Gentaur
Size: 100
10-043
Ruxolitinib . phosphate salt
Water-soluble phosphate salt of Ruxolitinib. Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro. It is investigated against the spread of the SARS-CoV-2 (COVID-19)
711.94 €