anti-GM-CSF Receptor alpha
803.4 EUR
In Stock
quantity
Produktdetaljer
Katalognummer: 1196 - YF-PA11126
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 50 ul
Parameters
| Storage and shipping | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
|---|
HA601033
Anti-GM-CSF Antibody [A6C5]
Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts that functions as a cytokine. Unlike granulocyte colony-stimulating factor, which specifically promotes neutrophil proliferation and maturation, GM-CSF affects more cell types, especially macrophages and eosinophils. GM-CSF is found in high levels in joints with rheumatoid arthritis and blocking GM-CSF as a biological target may reduce the inflammation or damage. Some drugs (e.g. otilimab) are being developed to block GM-CSF. In critically ill patients GM-CSF has been trialled as a therapy for the immunosuppression of critical illness, and has shown promise restoring monocyte and neutrophil function, although the impact on patient outcomes is currently unclear and awaits larger studies. GM-CSF stimulates monocytes and macrophages to produce pro-inflammatory cytokines, including CCL17. Elevated GM-CSF has been shown to contribute to inflammation in inflammatory arthritis, osteoarthritis, colitis asthma, obesity, and COVID-19.
465 €
DL91949A-100ul
Rabbit anti-GM-CSF Antibody
GMCSF; Granulocyte-macrophage colony-stimulating factor; GM-CSF; Colony-stimulating factor; CSF; Molgramostin; Sargramostim
598.5 €
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