Anti-Connexin-37 Antibody

ER1901-85

Anti-Connexin-37 Antibody

Connexins (Cxs) are a family of transmembrane proteins comprising 21 members in humans that forms gap junction channels (GJCs). Connexins are divided in four groups: α, β, γ and δ. Cx37 is also named α4 since it is the fourth connexin of the alpha group that was identified. Connexins do not function as single proteins; six connexins assemble into connexons (hemi-channels), and two connexons from neighboring cells dock in the extracellular space to form a full gap junction channel. Connexins are responsible for mediating direct communication between adjacent cells by the exchange of ions and small signaling molecules and cytosolic factors1,3. Their structure consists of four transmembrane helices, two extracellular loops, a cytoplasmic loop, a cytoplasmic NH2- and COOH-termini. Connexin-37 is encoded by the GJA4 gene and is expressed in vascular endothelial cells. The protein is responsible for regulating and controlling the growth, proliferation and regeneration of the vascular endothelium by mediating the signal transduction between smooth muscle and endothelial cells. Cx37 knockout mice have a tendency for developing endarterium atheromatous plaques4. Also, a polymorphism in the gene that encodes for Cx37, is associated with increased risk for atherosclerosis and myocardial infarction1.

433.5 €

STJ13100097

Anti-Connexin 37 antibody

918.6 €

STJ92408

Anti-Connexin 37 antibody

Rabbit polyclonal to Connexin 37.

504.6 €

STJ92410

Anti-Connexin 43 antibody

Rabbit polyclonal to Connexin 43.

504.6 €

STJ92411

Anti-Connexin 43 antibody

Connexin 43 is a protein encoded by the GJA1 gene which is approximately 43 kDa. Connexin 43 is localised to the cell membrane and endoplasmic reticulum. It is involved in gap junction trafficking and transport of connexins along the secretory pathway. It is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. In the heart these gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is expressed in the heart and foetal cochlea. Mutations in the GJA1 gene may result in Oculodentodigital dysplasia. STJ92411 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Connexin 43 protein.

504.6 €

STJ92412

Anti-Connexin 45 antibody

Rabbit polyclonal to Connexin 45.

504.6 €