79080

TPM3-TRKA Mutant, GST-Tag

Human TPM3-TRKA fusion protein, TPM3 GenBank Accession No. NM_152263, a.a. 1-258, TRKA Genbank Accession No. NM_002529, a.a. 399-end, expressed in an E. coli expression system. TMP3-TRKA MW = 105 kDa.

772.65 €

40415

Abl Kinase Mutant (T315I), His-tag

Human Abelson murine leukemia viral oncogene homolog 1 (Abl-1), GenBank Accession No. NM_005157, a.a. 229-512, with Thr-to-Ile mutation on a.a. 315* and N-terminal His-tag, MW = 33 kDa, expressed in a baculovirus-infected Sf9 cell expression system. *This mutation is often cited as T344I in variant B (GenBank Accession No. NM_007313).

689.33 €

NCP0116

Spike mutant protein:D364A,recombinant(hFc Tag)

The cause of the COVID-19 pandemic is a novel and highly pathogenic coronavirus, termed SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). SARS-CoV-2 is a member of the Coronaviridae family of viruses (1). The genome of SARS-CoV-2 is similar to other coronaviruses, and is comprised of four key structural proteins: S, the spike protein, E, the envelope protein, M, the membrane protein, and N, the nucleocapsid protein (2). Coronavirus spike proteins are class I fusion proteins and harbor an ectodomain, a transmembrane domain, and an intracellular tail. The highly glycosylated ectodomain projects from the viral envelope surface and facilitates attachment and fusion with the host cell plasma membrane. The ectodomain can be further subdivided into host receptor-binding domain (RBD) (S1) and membrane-fusion (S2) subunits, which are produced upon proteolysis by host proteases at S1/S2 and S2’ sites. S1 and S2 subunits remain associated after cleavage and assemble into crown-like homotrimers. In humans, both SARS-CoV and SARS-CoV-2 spike proteins utilize the angiotensin-converting enzyme 2 (ACE2) protein as a receptor for cellular entry. Spike protein subunits represent a key antigenic feature of coronavirus virions, and therefore represent an important target of vaccines, novel therapeutic antibodies, and small-molecule inhibitors.

401.98 €

chi-002

CHIKV Mutant

Recombinant Chikungunya Mutant (A226V) E1

393.90 €

enz-435

GSTO1 Mutant

Recombinant Human Glutathione S-Transferase Omega 1 Mutant

393.90 €

GWB-5203AB

p53 mutant

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